Profol 1%

Profol 1%

propofol

Manufacturer:

Baxter Pharma

Distributor:

Masu
Concise Prescribing Info
Contents
Propofol
Indications/Uses
Short-acting IV sedative-hypnotic & general anesth for induction & maintenance of general anesth. ICU & monitored anaesth care (MAC) sedation.
Dosage/Direction for Use
Individualized dosage. General anaesth Adult up to 55 yr &/or ASA I or II patients Induction: 2-2.5 mg/kg IV (approx 40 mg every 10 sec until onset of induction). Maintenance: 100-200 mcg/kg/min (6-12 mg/kg/hr). Elderly, debilitated, hypovolaemic &/or ASA III or IV patients Induction: 1-1.5 mg/kg IV (approx 20 mg every 10 sec until onset of induction). Maintenance: 50-100 mcg/kg/min (3-6 mg/kg/hr). 25-50 mg IV (intermittent) increments, as needed. Childn >8 yr Induction: Approx 2.5-3.5 mg/kg. Maintenance: 7.5-18 mg/kg/hr. MAC sedation Adult up to 55 yr &/or ASA I or II patients Initiation: 100-150 mcg/kg/min (6-9 mg/kg/hr). Maintenance: 1.5-4.5 mg/kg/hr. Elderly, ASA III or IV patients Initiation: Slow inj same to adults. Maintenance: Approx 20% reduction in adult dose. ICU sedation Initiation: 5 mcg/kg/min for at least 5 min w/ increments of 5-10 mcg/kg/min over 5-10 min until desired level of sedation is achieved or 10 mcg/kg/min over 5-10 min until desired level is achieved. Maintenance: 5-50 mcg/kg/min or higher.
Contraindications
Special Precautions
Monitor for early signs of hypotension, airway obstruction & oxygen desaturation; blood lipid levels. Patients w/ cardiac, resp, renal or hepatic impairment or hypovolaemic or debilitated patients. Concomitant use w/ agents that may cause bradycardia. Risk of convulsion in epileptic patients. Fat metabolism disorders. May impair ability to drive or operate machinery. Pregnancy & lactation.
Adverse Reactions
Hypotension, transient apnoea, burning in throat, wheezing, cough, hiccough. Nausea, vomiting, headache. Pulmonary oedema. 
Drug Interactions
Increased effects by narcotics (eg, morphine, meperidine, fentanyl) & combinations of opioids & sedatives (eg, benzodiazepines, barbiturates, chloral hydrate, droperidol). Increased anaesth or sedative & cardiorespiratory effects w/ isoflurane, enflurane & halothane.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01AX10 - propofol ; Belongs to the class of other general anesthetics.
Presentation/Packing
Form
Profol emulsion for infusion 1 %
Packing/Price
20 mL x 1's;50 mL x 1's
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