Profol 1%

Profol 1% Adverse Reactions

propofol

Manufacturer:

Baxter Pharma

Distributor:

Masu
Full Prescribing Info
Adverse Reactions
General: Induction of anaesthesia is generally smooth with minimal evidence of excitation. During induction of anaesthesia, hypotension and transient apnoea may occur depending on the dose and use of premedicants and other agents. Burning in throat, wheezing, cough, hiccough have been reported. During the recovery phase, nausea, vomiting and headache occur in only a small proportion of patients. Convulsions, including Myoclonus and opisthotonos, have been reported rarely and usually after termination of product. Rarely, clinical features of anaphylaxis, which may include angioedema, bronchospasm, erythema & hypotension, occur following PROFOL 1% administration. Pulmonary oedema has been observed. There have been reports of post-operative fever. Rarely, discoloration of urine has been reported following prolonged administration of PROFOL 1%.
Local: The local pain which may occur during the induction phase can be minimised by the use of the larger veins of the forearm and antecubital fossa. With PROFOL 1% local pain can also be minimised by the coadministration of lignocaine (see Administration under Dosage & Administration). Thrombosis and phlebitis are rare. Accidental clinical extravasation and animal studies with Propofol showed minimal tissue reaction. Intra-arterial injection in animals did not induce local tissue effects.
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