The induction dose requirements of PROFOL 1% may be reduced in patients with premedication with narcotics (eg, morphine, meperidine and fentanyl, etc.) and combinations of opioids and sedatives (eg, benzodiazepines, barbiturates, chloral hydrate, droperidol, etc). These agents may increase the anaesthetic or sedative effects of PROFOL 1% and may also result in more pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output. During maintenance of anaesthesia or sedation the rate of PROFOL 1% administration should be adjusted according to the desired level of sedation and may be reduced in the presence of supplemental analgesic agents (eg, nitrous oxide or opioids). The concurrent administration of inhalational agents (eg, isoflurane, enflurane, and halothane) during maintenance is expected to increase the anaesthetic or sedative and cardiorespiratory effects of PROFOL 1%. PROFOL 1% does not cause a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents (eg, succinyl choline and nondepolarizing muscle relaxants). No significant adverse reactions with commonly used premedication or drugs used during anaesthesia or sedation (including a range of muscle relaxants, inhalational agents, analgesics, and local anaesthetics) have been observed.