ProQuad

ProQuad

Manufacturer:

MSD

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Measles, mumps, rubella & varicella (Oka/Merck) virus vaccine live (Each 0.5 mL contains measles virus not less than 3 log10 TCID50, mumps virus 4.3 log10 TCID50, rubella virus 3 log10 TCID50, Oka/Merck varicella virus 3.99 log10 PFU)
Indications/Uses
Vaccination against measles, mumps, rubella & varicella in childn 12 mth to 12 yr.
Dosage/Direction for Use
SC Childn 12 mth to 12 yr single dose, 6 to <12 mth If 1st dose is given at this age, 2nd dose should be administered at 12 mth or later.
Contraindications
Hypersensitivity to the vaccine, including gelatin. History of anaphylactoid reaction to neomycin. Blood dyscrasias, leukemia, lymphomas of any type, or other malignant neoplasms affecting the bone marrow or lymphatic system. Immunosuppressive therapy (including high-dose corticosteroids). Primary & acquired immunodeficiency states, including immunosuppression in association w/ AIDS or other clinical manifestations of infection w/ HIV; cellular immune deficiencies; & hypogammaglobulinemic & dysgammaglobulinemic states. Family history of congenital or hereditary immunodeficiency. Active untreated TB. Any active febrile illness w/ fever >38.5°C. Pregnancy (3 mth following vaccination).
Special Precautions
Do not give Ig or varicella zoster Ig w/ ProQuad. Do not inj intravascularly. Hypersensitivity to eggs. Avoid in patients w/ history of convulsions, cerebral injury or any other condition in which stress due to fever. HIV w/ or w/o evidence of immunosuppression. Avoid close association w/ high-risk individuals (eg, immunocompromised individuals, pregnant women & their newborn w/o documented positive history of varicella or lab evidence of prior varicella infection) for up to 6 wk following vaccination. Carefully evaluate before considering vaccination in individuals w/ thrombocytopenia. Administer tuberculin test prior to or at least 4-6 wk after ProQuad; temporary depression of tuberculin skin sensitivity. Females of childbearing age should avoid pregnancy 3 mth following vaccination. Lactation. Not recommended for infant <12 mth. Defer vaccination at least 3 mth following blood/plasma transfusion or Ig administration & 5 mth for VZIg. Any Ig including VZIg should not be given for 1 mth following therapy.
Adverse Reactions
Fever ≥38.9°C, erythema or pain/tenderness/soreness at the inj site. Upper resp infection; irritability; diarrhea, vomiting; measles-like rash, rash, varicella-like rash; ecchymosis or swelling at the inj site, inj site rash.
Drug Interactions
May interfere w/ the expected immune response w/ Ig. Risk of Reye syndrome w/ salicylates (6 wk after vaccination).
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07BD54 - measles, combinations with mumps, rubella and varicella, live attenuated ; Belongs to the class of measles vaccines.
Presentation/Packing
Form
ProQuad powd for inj
Packing/Price
((lyo) + 0.7 mL diluent) 0.5 mL x 1's
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