Pulmicort Turbuhaler

Pulmicort Turbuhaler Mechanism of Action





Full Prescribing Info
Budesonide is a glucocorticosteroid with a high local anti-inflammatory effect. Budesonide undergoes an extensive degree (~90%) of biotransformation in the liver to metabolites of low glucocorticosteroid activity. The glucocorticosteroid activity of the major metabolites, 6β-hydroxybudesonide and 16α-hydroxyprednisolone, is <1% of that of budesonide.
Budesonide has shown antianaphylactic and anti-inflammatory effects in provocation studies in animals and patients, manifested as decreased bronchial obstruction in the immediate as well as the late allergic reaction.
Budesonide has also been shown to decrease airway reactivity to histamine and methacholine in hyper-reactive patients. Therapy with inhaled budesonide has effectively been used for prevention of exercise-induced asthma. After a single dose, improvement of the lung function is achieved within a few hours.
Full effect of budesonide, as for other glucocorticosteroids is, however, not achieved until after a couple of days. About 10% of the dose is deposited in the lungs. Of the fraction which is swallowed, 90% is inactivated at first passage through the liver. The maximal plasma concentration after inhalation of 1 mg budesonide is <0.01 micromole/L and is reached within 30 min.
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