Usual dosages for treatment of infection: Adults and children over 12 years: 625-mg FC tab: Mild-Moderate Infections: One RANCLAV 625 mg tablet two times a day.
For more severe infections and infections of respiratory tract, the usual oral dosage is one tablet containing 500 mg of amoxicillin and 125 mg of clavulanic acid (One Ranclav 625 tablet) every 8 hours.
1-g FC tab: Severe infections: One RANCLAV 1 G tablet two times a day.
Therapy can be started parenterally and continued with an oral preparation.
Dosage in dental infections (e.g. dentoalveolar abscess): Adults and children over 12 years: One RANCLAV 1 G tab two times a day for five days.
RANCLAV 625 mg and 1 G tab are not recommended in children of 12 years and under.
Dosage in renal impairment: Adults: The RANCLAV 1 G tab should only be used in patients with a glomerular filtration rate of >30 mL/min.
Mild impairment (Creatinine clearance >30 ml/min): No change in dosage (i.e. either one 625 tablet bid or one 1 G tablet bid).
Moderate impairment (Creatinine clearance 10-30 ml/min): One 625 mg tab bid. The 1 G tab should not be administered.
Severe impairment (Creatinine clearance <10 ml/min): Not more than one 625 mg tablet every 24 hrs.
Dosage in hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
Oral administration: Tablets should be swallowed whole without chewing. If required, tablets may be broken in half and swallowed without chewing. To minimize potential gastrointestinal intolerance, administer at the start of a meal. The absorption of Amoxicillin and Clavulanate Potassium combination is optimised when taken at the start of a meal. Treatment should not be extended beyond 14 days without review.
Susp: The usual recommended daily dosage is: Adult and Children (weight > 40 kg): oral 250-500 mg (amoxicillin) every 8 hours or 500-875 mg (amoxicillin) every 12 hours. Maximum dose is 2-3 gram/day.
Children (weight <40 kg): Oral 20-50 mg/kg/day divided every 8-12 hours or 125-250 mg (amoxicillin) every 8 hours or 200-400 mg (amoxicillin) every 12 hours.
Renal impairment: See table.
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