625-mg FC tab: Probenecid: Oral probenecid administered shortly before or concomitantly with amoxicillin & clavulanic acid slows the rate of renal tubular secretion of amoxicillin and produces higher and prolonged serum concentrations of amoxicillin.
However, concomitant administration of probenecid with amoxicillin & clavulanate potassium combination does not affect the area under the serum concentration time curve (AUC), half-life or peak serum concentration of clavulanic acid.
Allopurinol: An increased incidence of rash has been reported in patients with hyperuricemia who are receiving allopurinol and concomitant amoxicillin or ampicillin. Therefore, some clinicians suggest that concomitant use of the drugs should be avoided, if possible.
1-g FC tab and Susp: Prolongation of bleeding time and prothrombin time may occur in some patients receiving Amoxicillin and Clavulanate combination. This combination should be used with caution in patients receiving anti-coagulant therapy. An increased incidence of rash may occur in patients with hyperuricemia who are receiving allopurinol and concomitant Amoxicillin or Ampicillin.
In common with other broad spectrum antibiotics, Amoxicillin and Clavulanate Potassium combination may reduce the efficacy of oral contraceptives. Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of Amoxicillin.
Concomitant use with RANCLAV may result in increased and prolonged blood levels of Amoxicillin but not of Clavulanic acid.