MAOIs. Serotonin syndrome may occur w/ serotonergic drugs (eg, L-tryptophan, triptans, tramadol, linezolid, methylene blue, SSRIs, venlafaxine, lithium & St. John's wort). May increase sedating properties of benzodiazepines & other sedatives (eg, antipsychotics, histahime H1
-antagonists, opioids). May increase CNS depressant effect of alcohol. Increased INR w/ warfarin. Increased risk of QT prolongation &/or ventricular arrhythmias w/ QTc interval prolonging drugs (eg, some antipsychotics & antibiotics). Increased clearance w/ CYP3A4 inducers eg, carbamazepine & phenytoin. Increased peak plasma levels & AUC w/ potent CYP3A4 inhibitors eg, ketoconazole. Increased mean plasma conc w/ potent CYP3A4 inhibitors, HIV PIs, azole antifungals, erythromycin, cimetidine or nefazodone.