RA Initially 3 mg/kg IV infusion over 2 hr followed w/ 3 mg/kg administered 2 & 6 wk after 1st infusion then every 8 wk thereafter. For patients who have an incomplete response, consideration may be given to adjusting the dose up to 10 mg/kg &/or treating as often as every 4 wk. Should be given in combination w/ MTX.
Adult or Ped Crohn's disease or adult fistulizing Crohn's disease Induction regimen: 5 mg/kg as single IV infusion over 2 hr at 0, 2 & 6 wk. Maintenance regimen: 5 mg/kg every 8 wk thereafter. For patients who have an incomplete response, consideration may be given to adjusting the dose up to 10 mg/kg.
Ped Crohn's disease 5 mg/kg as IV infusion followed by additional 5 mg/kg infusion doses at 2 & 6 wk after the 1st infusion then every 8 wk thereafter. In incomplete response, dose may be adjusted up to 10 mg/kg.
Ankylosing spondylitis 5 mg/kg IV infusion over 2 hr followed by 5 mg/kg doses administered at 2 & 6 wk after 1st infusion then every 6 wk thereafter.
Plaque, psoriasis, psoriatic arthritis 5 mg/kg IV infusion over 2 hr followed by additional 5 mg/kg infusion at 2 & 6 wk after the 1st infusion then every 8 wk thereafter.
Adult or ped Ulcerative colitis 5 mg/kg IV infusion over 2 hr followed by additional 5 mg/kg infusion at 2 & 6 wk after the 1st infusion then every 8 wk thereafter. For adult patients who have an incomplete response or lose their response, consideration may be given to treatment 10 mg/kg.
Re-administration for Crohn's disease & RA May be re-administered w/in 16 wk following last infusion if signs & symptoms recur.
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