Individualized dosage. Adult Initially, 2 mg once daily for 1 wk, increased by increments of up to 4 mg once every 1-2 wk as necessary. Max: 24 mg once daily. Patients w/ end-stage renal disease Initially 2 mg once daily. Max: 18 mg/day.
Hepatic impairment. Severe CV disease; history or presence of major psychotic disorders & compulsive behaviours or concurrent dopaminergic treatment. Rapid GI transit. May impair ability to drive or operate machinery. Smoking. Pregnancy & lactation. Patient <18 yr.
Effectiveness may be diminished by neuroleptics & other centrally active dopamine antagonists eg, sulpiride or metoclopramide. Increased Cmax & AUC w/ ciprofloxacin. Increased plasma conc w/ oestrogens. Alcohol.