Begin 24 hr after termination of methotrexate therapy. Usually 15 mg 3 hrly IV for 1st 24 hr. Then, one 15 mg tab 6 hrly for 48 hr. Megaloblastic anemia
Initially 10 mg daily for 10-15 days, then adjust dosage according to hematological response. Metastasised colorectal carcinoma
Wkly schedule: 20-200 mg/m2
in a 2 hr infusion w/ 500 mg/m2
5-FU as bolus inj. Mthly schedule: 20 or 200 mg/m2
bolus immediately followed by 425 or 370 mg/m2
5-FU bolus once a mth for 5 consecutive days.