Rifafour e-275

Rifafour e-275

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Rifampicin 150 mg, INH 75 mg, pyrazinamide (PZA) 400 mg, ethambutol 275 mg
Indications/Uses
Initial & re-treatment phase of pulmonary & extrapulmonary TB in adults.
Dosage/Direction for Use
2-mth initial phase Adult & childn ≥13 yr, ≥71 kg 5 tab daily, 55-70 kg 4 tab daily, 38-54 kg 3 tab daily, 30-37 kg 2 tab daily.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals w/ a full glass of water. May be taken w/ meals if GI irritation occurs.
Contraindications
Hypersensitivity. Jaundice or preexisting liver disorders, optic neuritis. Childn <13 yr. Pregnancy & lactation.
Special Precautions
Impaired kidney & hepatic function, visual defects, history of gout & psychosis, neuropathy or pyridoxine deficiency, patients with epilepsy, porphyria & diabetes, elderly.
Adverse Reactions
GI disturbances, hypersensitivity reactions, neurologic effects. Rifampicin: Cutaneous reactions, pseudomembranous colitis, hepatitis, changes in renal & hepatic function, hematological effects, orange-red discoloration urine & other body fluids. INH: Peripheral neuropathy, hematological effects. PZA: Hepatotoxicity, hyperuricemia. Ethambutol: Retrobulbar neuritis, reduced renal clearance of urate.
Drug Interactions
Rifampicin: Induces microsomal enzymes (accelerates clearance of methadone, oral anticoagulants, glucocorticoids, oestrogen, oral hypoglycaemic agents, digitoxin, antiarrhythmics, theophylline, anticonvulsants, β-blockers, azole antifungal, cyclosporin). INH: Inhibits metabolism of antiepileptics, benzodiazepines, warfarin, theophylline. Increases metabolism of enflurane. Alcohol, ASA, Al-containing antacids, corticosteroids, ketoconazole, propranolol. PZA: Decreases efficacy of gout therapy agents. Ethambutol: Neurotoxic agents.
MIMS Class
ATC Classification
J04AM06 - rifampicin, pyrazinamide, ethambutol and isoniazid ; Belongs to the class of combination drugs used in the systemic treatment of tuberculosis.
Presentation/Packing
Form
Rifafour e-275 tab
Packing/Price
6 × 14's
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