Proteinuria. Skeletal muscle effects eg, uncomplicated myalgia, myopathy & rarely rhabdomyolysis. Predisposing factors for rhabdomyolysis or myopathy eg, hypothyroidism, personal or family history of muscular disorders, previous history of muscular toxicity w/ another HMG-CoA reductase inhibitor or fibrate. Excessive alcohol consumption. Acute, serious conditions suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis. Renal impairment. History of liver disease. Childn. Elderly >70 yr.