Gastrointestinal symptoms nausea, vomiting, epigastric pain. diarrhea, very rarely bloody. In isolated cases, symptoms of pancreatitis have been observed; most patients had received other drugs for which pancreatitis is a known adverse reaction.
Hypersensitivity reactions: as with other macrolide antibiotics, rash, urticaria, angio-oedema; exceptionally purpura, bronchospasm, anaphylactic shock.
Dizziness, headache, paraesthesia.
Moderate increases in ASAT, ALAT and/or alkaline phosphatase, Cholestatic or, more rarely, hepatocellular acute hepatitis. As with other macrolides, disturbances of taste and/or smell have been reported.
Superinfection as with other antibiotics, the use of roxithromycin, especially if prolonged, may result in overgrowth of non-susceptible organisms. Repeated evaluation of the patient's condition is essential. If superinfection occurs during therapy, appropriate measures should be taken.