Ruxolitinib - oral

Patient Medicine Information
Why do I need this medicine?
Ruxolitinib is used to treat myelofibrosis, a serious bone marrow disorder.

This medicine is also used to treat polycythaemia vera, a rare blood disease in which the body makes too many red blood cells.
How do I take this medicine?
Take this medicine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Inform your doctor if you have difficulty swallowing. Your doctor will decide if you can take Ruxolitinib through a nasogastric tube.

How to administer this medicine via a nasograstric tube:
  1. Disperse 1 tablet in approximately 40 mL of water and stir for 10 minutes.
  2. Within 6 hours after dispersion, administer Ruxolitinib with appropriate syringe.
  3. After administration, rinse the nasogastric tube with approximately 75 mL of water.
Ruxolitinib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
What should I do if I have forgotten to take this medicine?
If you missed a dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take Ruxolitinib if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Ruxolitinib may cause harm to your unborn child. You must use proven birth control methods while taking this medicine.

Do not breastfeed while you are being treated with this medicine and 2 weeks after your last dose.
What should I take note of while taking this medicine?
Inform your doctor if you have the following conditions:
  • liver disease
  • kidney disease
  • tuberculosis or history or risk of tuberculosis
  • hepatitis B infection
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. Your doctor may also need to do routine blood tests (e.g. complete blood count, blood cholesterol levels), liver and kidney function tests while you are being treated with this medicine.
What side effects could I experience?
Ruxolitinib may cause dizziness and weakness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, tiredness, difficulty sleeping, bruising, itching, diarrhoea, constipation, nausea, vomiting, stomach pain, muscle spasm, shortness of breath, weight gain, sore throat, cough, and bleeding from the nose.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • sore that doesn’t heal
  • mental slowness, vision loss, speech disturbances, inability to control movements
  • sudden severe headache, seizures
  • pass out blood or black, tarry stools or vomit coffee-ground-like vomitus
  • unusual bleeding or bruising
  • signs of infection (e.g. fever, chills, burning or pain when urinating)
  • painful rash or blisters
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for fungal infection e.g. itraconazole, ketoconazole, posaconazole, voriconazole
  • medicines for HIV infection e.g. lopinavir, ritonavir, nelfinavir, saquinavir, amprenavir, atazanavir
  • certain antibiotics e.g. clarithromycin, telithromycin, erythromycin, ciprofloxacin
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenytoin, phenobarbital
  • medicines for tuberculosis or TB e.g. rifampicin medicines for heart disease e.g. digoxin, diltiazem
  • medicine for organ transplant and immune disorders e.g. ciclosporin
  • blood thinning medicine e.g. dabigatran
  • herbal medicines e.g. St. John’s wort
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol and grapefruit juice.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.
This information is independently developed by MIMS based on ruxolitinib - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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