The dosage is as follows unless otherwise prescribed by the physician:
The individual maintenance dose should be determined under cardiological surveillance including ECG monitoring and repeated blood pressure control (adjustment phase). If the QRS phase is prolonged by >20% or the rate-dependent QT interval is lengthened, the dose should be reduced or discontinued until the ECG returns to normal. For initial and maintenance treatment, dose of 150-300 mg twice or thrice daily is recommended. This daily dose should be exceeded only in exceptional circumstances and under strict cardiological control.
These data apply to patients with a body weight of about 70 kg. The daily doses are to be reduced accordingly for patients with a lower body weight.
In the elderly or in patients with marked previous myocardial damage, the dose of Rytmonorm should, in conformity with other antiarrhythmic agents, be increased only slowly and gradually during the initial phase of treatment.
Because of the bitter taste and the surface anaesthetic action of propafenone, the tablets should be swallowed whole together with some liquid after meals.