Bone marrow transplantation
Adult: 250 mcg/m2 daily by IV infusion over 2 hr. If engraftment is delayed or has failed, a 14-day course at 250 mcg/m2 daily may be given. Course may be repeated after a 7-day interval if engraftment has not occurred. A 3rd course at 500 mcg/m2/day may be given for 14 days after another 7-day interval, if needed. Further dose increment may not be beneficial.
Adult: 250 mcg/m2 daily for up to 42 days as required, to be given as IV infusion over 4 hr.
Mobilisation of peripheral blood progenitor cells
Adult: 250 mcg/m2 daily by continuous IV infusion over 24 hr or once daily by SC inj with leucapheresis usually starting on day 5 and continued daily until protocol specified targets are reached. Reduce dose by half if WBC>50,000 cells/mm3. Consider other mobilisation therapy if the numbers of progenitor cells that are collected are inadequate.