Observe for evidence of glucose intolerance. Test thyroid function after starting treatment & after dose adjustments. Optimize cortisol replacement therapy prior to treatment. Signs of relapse of malignant disease. Slipped epiphyses of the hip may occur. Discontinue if papilloedema develops & consider diagnosis of benign intracranial HTN, if signs of upper airway obstruction (onset of or increased snoring) develops, & at renal transplantation. Patients w/ PWS should be evaluated for upper airway obstruction sleep apnoea or resp infections before starting treatment. Monitor for scoliosis. Measure fasting insulin & blood glucose annually & IGF-1 twice a year, prior to treatment in SGA childn. SGA patients near onset of puberty. Maintain control of acidosis, hyperparathyroidism & nutritional status for renal insufficiency during treatment. Acute critically ill patients. Pregnancy & lactation.