Sedol

Sedol Dosage/Direction for Use

etoposide

Manufacturer:

Venus Remedies

Distributor:

Cosma Medical

Marketer:

Cosma Medical
Full Prescribing Info
Dosage/Direction for Use
The usual dose of SEDOL in testicular cancer in combination with other approved chemotherapeutic agents ranges from 50 to 100 mg/m2/day on days 1 through 5 to 100 mg/m2/day on days 1, 3, and 5.
In small cell lung cancer, the SEDOL in combination with other approved chemotherapeutic drugs ranges from 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days.
Chemotherapy courses are repeated at 3 to 4-week intervals after adequate recovery from any toxicity.
Mode of Administration: Administration Precautions: As with other potentially toxic compounds, caution should be exercised in handling and preparing the solution of SEDOL. Skin reactions associated with accidental exposure to SEDOL may occur. The use of gloves is recommended. If SEDOL solution contacts the skin or mucosa, immediately and thoroughly wash the skin with soap and water and flush the mucosa with water.
Dosage adjustment: The dosage of etoposide should be adjusted taking into account the myelosuppressive effects of other drugs in combination, or the effects of prior radiation or chemotherapy which may have compromised bone marrow reserve, clinical effect and patient tolerance.
Use in patient with renal impairment: In patients with impaired renal function, the following initial dose modification should be considered based on measured creatinine clearance: see Table.

Click on icon to see table/diagram/image

Subsequent SEDOL dosing should be based on patient tolerance and clinical effect.
Data are not available in patients with creatinine clearances <15 mL/min and further dose reduction should be considered in these patients.
Preparation for Intravenous Administration: SEDOL For Injection must be diluted prior to use with either 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP, to give a final concentration of 0.2 to 0.4 mg/mL. If solutions are prepared at concentrations above 0.4 mg/mL, precipitation may occur.
Hypotension following rapid intravenous administration has been reported, hence, it is recommended that the SEDOL solution be administered over a 30- to 60-minute period.
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