Sefpime

Sefpime

cefepime

Manufacturer:

Sinopharm Zhijun (Shenzhen)

Distributor:

S Charoen Bhaesaj Trading
Concise Prescribing Info
Contents
Cefepime HCl
Indications/Uses
Lower resp tract, skin & skin structure, intra-abdominal, gynecologic & obstet infections; UTI, empiric treatment in febrile neutropenia; septicemia; bacterial meningitis in childn >2 mth to 16 yr.
Dosage/Direction for Use
IV Adult & childn ≥40 kg 1-2 g 12 hrly for 7-10 days. Mild or moderate UTI 0.5-1 g 12 hrly for 7-10 days. Severe UTI 2 g 12 hrly for 10 days. Empiric treatment of febrile neutropenia complicated w/ fever Adult 2 g 8 hrly for 7-10 days or until neutropenia is controlled. Childn 2 mth up to 12 yr Max: 2 g, weighing >40 kg 50 mg/kg 12 hrly for 7-14 days. Neutropenic childn 50 mg/kg 8 hrly. Ped patients >2 mth 100-150 mg/kg daily divided in 3 dose, 1-2 mth 30 mg/kg 8-12 hrly. Patients w/ impaired renal function w/ CrCl 30-60 mL/min 0.5-1 g every 24 hr alternatively, 2 g every 12 or 24 hr, 11-29 mL/min 0.5-2 g every 24 hr, <11 mL/min 0.25-1 g every 24 hr. Patients on hemodialysis Administer a loading dose of 1 g on the 1st day, then 0.5 g/day.
Contraindications
Hypersensitivity to cefepime, cephalosporins, L-arginine, penicillins & β-lactam antibiotics.
Special Precautions
History of allergy. Consider pseudomembranous enteritis if diarrhea occurs. Patients w/ GI disease especially enteritis. Monitor prothrombin time on patients w/ liver & renal insufficiency, malnutrition & on prolonged antibacterial treatment; renal function in patients using concomitant aminoglycosides or strong diuretics. Glucose metabolic disorder & transient increase in blood K. May impair ability to drive or operate machinery. Pregnancy & lactation. Should not be used in ped patients for treatment of serious infections that are suspected or known to be caused by H. influenzae type B.
Adverse Reactions
Diarrhea, skin rash, local reaction at inj site eg, phlebitis, pain or inflammation, nausea, vomiting, anaphylaxis, pruritus, fever, paresthesia & headache. Enteritis (including pseudomembranous enteritis) & oral candidiasis. Abnormal hepatic or renal laboratory tests, Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis. Seizures.
Drug Interactions
May induce nephrotoxicity or ototoxicity w/ aminoglycosides. Concomitant use w/ strong diuretics.
MIMS Class
ATC Classification
J01DE01 - cefepime ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Sefpime powd for inj 1 g
Packing/Price
10 × 1's
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