For adults and children of 40kg or >40kg: 1~2g/time, q12h, IV for 7~10 days.
For mild or moderate urinary tract infections, 0.5~1g/time, q12h, IV for 7~10 days.
For severe urinary tract infections, 2g/time, q12h, IV for 10 days.
For empirical treatment in febrile neutropenia complicated with fever, IV 2g/time, q8h, for 7~10 days or until neutropenia is controlled. If the fever is brought down while the level of neutrophilic granulocytes is till abnormally low, the use of antibiotic should be re-evaluated. The maximum dose for children of 2 months up to 12 years of age should not exceed that of adults (2g/time). Children >40kg may use dose of adults, usually 50mg/kg, IV q12h for 7~14 days; for neutropenic children, 50mg/kg, q8h.
Experience with the use of cefepime in pediatric patients <2 months of age is limited, while this experience attained in patients >2 months of age suggested that a dosage of 100-150 mg/kg daily divided in 3 dose, a dosage of 30 mg/kg q12h or q8h may be considered for patients aged 1 month up to 2 months with careful monitoring.
Adjustment in dosage is not necessary in patients with impaired hepatic function.
For patients with impaired renal function, the initial dose of cefepime is the same as in patients with normal renal function. The recommended doses of cefepime in patients with renal insufficiency are presented in the following table: see Table.
Click on icon to see table/diagram/image
The data of use of cefepime in children with impaired renal function is not available. Due to similar pharmacokinetics between children and adults, the dosage for adults with renal impairment is recommended for children with renal impairment.
For direct IV injection, the 1g vial should be constituted with 10 ml of Sterile Water for Injection, 5% Dextrose Injection or 0.9% Sodium Chloride Injection. The resulting solution should be injected directly into the vein over a period of 3-5 min or injected into the tubing of an administration set while the patient is receiving a compatible IV fluid.
For IV infusion, the 1g vial should be constituted as noted previously for direct IV Injection, then add the appropriate quantity of the resulting solution to an IV container with one of the following compatible IV fluids to obtain solutions with concentrations between 1 and 40 mg/ml: 0.9% Sodium Chloride Injection, 5% and 10% Dextrose Injection, M/6 Sodium Lactate Injection, 5% Dextrose and 0.9% Sodium Chloride Injection, Lactated Ringer's and 5% Dextrose Injection.
These solutions are stable for 24 hours when stored at room temperature (<25°C ) or 7 days when stored under refrigeration (2~8°C).