HIGHLIGHT
Semglee

Semglee

insulin glargine

Manufacturer:

Biocon

Distributor:

DKSH

Marketer:

Viatris
Concise Prescribing Info
Contents
Insulin glargine
Indications/Uses
DM in adults, adolescents & childn ≥2 yr.
Dosage/Direction for Use
SC Individualized dose. Administer once daily at the same time each day. Switch from bid NPH insulin to Semglee Reduce 20-30% of daily dose of basal insulin during the 1st wk of treatment. Switch from insulin glargine 300 u/mL to Semglee Reduce dose by approx 20%.
Contraindications
Special Precautions
Not to be administered IV. Not to be mixed or diluted w/ other insulin. Not for diabetic ketoacidosis. Hyper- & hypoglycaemia. Patients w/ significant stenoses of coronary arteries or risk of cardiac or cerebral hypoglycemic complications; proliferative retinopathy; in whom glycaemic control is markedly improved & hypoglycaemia develops gradually. Autonomic neuropathy, long history of diabetes, psychiatric illness; changed in inj area, improved insulin sensitivity, unaccustomed, increased or prolonged physical activity, intercurrent illness, inadequate food intake, missed meals, alcohol consumption. Uncompensated endocrine disorders eg, hypothyroidism & anterior pituitary or adrenocortical insufficiency. Transferring from animal to human insulin. Monitor blood glucose. Combination w/ pioglitazone. May affect ability to drive & use machines. Renal & hepatic impairment. Careful glucose monitoring during pregnancy. Lactation. Childn <2 yr. Elderly ≥65 yr.
Adverse Reactions
Hypoglycemia. Lipohypertrophy; inj site reaction.
Drug Interactions
Enhanced blood glucose-lowering effect & increased susceptibility to hypoglycaemia by oral antidiabetics, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates & sulfonamide antibiotics. Reduced blood glucose-lowering effect by corticosteroids, danazol, diazoxide, diuretics, glucagon, INH, oestrogens & progestogens, phenothiazine derivatives, somatropin, sympathomimetics (eg, epinephrine, salbutamol, terbutaline), thyroid hormones, atypical antipsychotics (eg, clozapine & olanzapine) & PIs. Potentiated or weakened blood glucose-lowering effect by β-blockers, clonidine, lithium salts or alcohol; pentamidine. Reduced or absent signs of adrenergic counterregulation w/ β-blockers, clonidine, guanethidine & reserpine.
MIMS Class
Insulin Preparations
Presentation/Packing
Form
Semglee soln for inj 100 u/mL
Packing/Price
(3 mL) 5's
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