Seroquel XR

Seroquel XR

quetiapine

Manufacturer:

AstraZeneca

Distributor:

DKSH
Concise Prescribing Info
Contents
Quetiapine fumarate
Indications/Uses
Schizophrenia. Prevention of relapse in stable schizophrenic patients who have been maintained on Seroquel XR. Bipolar disorder including manic & depressive episodes associated w/ bipolar disorder; prevention of recurrence in maintenance treatment of bipolar disorder (manic, mixed or depressive episode) as monotherapy or in combination w/ mood stabilizers (lithium or valproate). Major depressive disorder. Prevention of relapse in stable major depressive disorder patients who have been maintained on Seroquel XR.
Dosage/Direction for Use
Adult Schizophrenia & manic episodes associated w/ bipolar disorder 300 mg (day 1), 600 mg (day 2) & up to 800 mg after day 2; may be adjusted w/in 400-800 mg/day. Depressive episodes associated w/ bipolar disorder Administer once daily in the evening. Dose titration: 50 mg (day 1), 100 mg (day 2), 200 mg (day 3), 300 mg (day 4); may be titrated to 400 mg (day 5) & up to 600 mg (day 8). Maintenance treatment of bipolar disorder; combination w/ mood stabilizers (lithium or valproate) Total daily dose: 400-800 mg/day. Monotherapy: Total daily dose: 300-800 mg/day. Major depressive disorder Administer once daily in the evening. Dose titration: 50 mg (day 1, day 2), 150 mg (day 3, day 4), may be adjusted w/ in 50-300 mg/day (day 5). Maintenance therapy in major depressive disorder Effective dose during initial treatment should be continued. Elderly & hepatic impairment Start w/ 50 mg/day, may be increased in increments of 50 mg/day. Elderly w/ major depressive disorder 50 mg on days 1-3, may be increased to 100 mg on day 4, 150 mg on day 8 & then up to 300 mg.
Administration
May be taken with or without food: May be taken w/ a light meal. Swallow whole, do not split/chew/crush.
Special Precautions
Carefully monitor patients w/ history of suicide-related events, or those exhibiting a significant degree of suicidal ideation prior to start of treatment. Neutropenia, DM (hyperglycaemia may occur). Discontinue use in patients w/ neutrophil count <1 x 109/L. Increases in triglycerides & cholesterol; decreased in HDL. Pancreatitis. CV & cerebrovascular disease, other conditions predisposing to hypotension. Patients at risk for aspiration pneumonia. History of seizures, extrapyramidal symptoms & tardive dyskinesia, neuroleptic malignant syndrome. Patients w/ CV disease or family history of QT prolongation; concomitant use w/ drugs known to increase QT interval, or neuroleptics. Avoid abrupt w/drawal. Elderly w/ dementia; congenital long QT syndrome, CHF, heart hypertrophy, hypokalemia or hypomagnesemia. May impair ability to drive & use machines. Pregnancy & lactation. Childn 10-17 yr.
Adverse Reactions
Dry mouth; w/drawal symptoms; elevations in serum triglyceride levels & total cholesterol, decrease in HDL cholesterol, wt gain; dizziness, somnolence. Leukopenia; tachycardia; blurred vision; constipation, dyspepsia; mild asthenia, peripheral edema, irritability; elevations in serum transaminases (ALT, AST), decreased neutrophil count, increased blood glucose, elevations in serum prolactin; syncope, extrapyramidal symptoms, dysarthria; increased appetite, rhinitis; orthostatic hypotension; abnormal dreams & nightmares.
Drug Interactions
Decreased systemic exposure w/ carbamazepine. Higher plasma conc w/ potent CYP3A4 inhibitors eg, azole antifungals, macrolides & PIs. Centrally-acting drugs & alcohol, drugs known to cause electrolyte imbalance or to increase QT interval. Increased clearance w/ phenytoin.
MIMS Class
Antipsychotics / Antidepressants
ATC Classification
N05AH04 - quetiapine ; Belongs to the class of diazepines, oxazepines and thiazepines antipsychotics.
Presentation/Packing
Form
Seroquel XR tab 150 mg
Packing/Price
60's
Form
Seroquel XR tab 300 mg
Packing/Price
60's
Form
Seroquel XR tab 400 mg
Packing/Price
6 × 10's
Form
Seroquel XR tab 50 mg
Packing/Price
60's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in