Seroquel XR

Seroquel XR Dosage/Direction for Use

quetiapine

Manufacturer:

AstraZeneca

Distributor:

DKSH
Full Prescribing Info
Dosage/Direction for Use
Seroquel XR should be administered once daily, with or without food. The tablets should be swallowed whole and not split, chewed or crushed.
Adults: For the treatment of schizophrenia: The daily dose at the start of therapy is 300 mg on Day 1; 600 mg on Day 2 and up to 800 mg after Day 2. The dose should be adjusted within the effective dose range of 400 mg to 800 mg per day, depending on the clinical response and tolerability of the patient. For maintenance therapy in schizophrenia no dosage adjustment is necessary.
For the treatment of manic episodes associated with bipolar disorder: The daily dose at the start of therapy is 300 mg on Day 1; 600 mg on Day 2 and up to 800 mg after Day 2. The dose should be adjusted within the effective dose range of 400 to 800 mg per day, depending on the clinical response and tolerability of the patient.
For the treatment of depressive episodes associated with bipolar disorder: Seroquel XR should be administered once daily in the evening.
Seroquel XR should be titrated as follows: 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4).
Seroquel XR can be titrated to 400 mg on Day 5 and up to 600 mg by Day 8.
Antidepressant efficacy was demonstrated with Seroquel at 300 mg and 600 mg, however no additional benefit was seen in the 600 mg group during short-term treatment (see Adverse Reactions and Pharmacology: Clinical Efficacy under Actions).
For preventing recurrence in maintenance treatment of bipolar disorder: Patients who have responded to Seroquel XR in combination therapy to a mood stabilizer (lithium or valproate) for acute treatment of bipolar disorder should continue on Seroquel XR therapy at the same dose. The Seroquel XR dose can be re-adjusted depending on clinical response and tolerability of the individual patient within the dose range of 400 mg to 800 mg/day. Patients who have responded to Seroquel XR for acute treatment of bipolar disorder should continue on Seroquel XR therapy at the same dosing regimen. Seroquel XR dose can be re-adjusted depending on clinical response and tolerability of the individual patient within the dose range of 300 mg to 800 mg/day.
For the treatment of major depressive disorder: Seroquel XR should be administered once daily in the evening.
Initial dosing should begin at 50 mg on Day 1 and 2, increased to 150 mg on Day 3 and 4. Further adjustments can be made upwards or downwards within the recommended dose range of 50 mg to 300 mg depending upon the clinical response and tolerability of the patient.
For maintenance therapy in major depressive disorder the effective dose during initial treatment should be continued. The dose can be adjusted within the recommended dose range depending upon the clinical response and tolerability of the patient.
Switching from Seroquel immediate-release tablets: For more convenient dosing, patients who are currently being treated with divided doses of Seroquel immediate-release tablets (Seroquel) may be switched to Seroquel XR at the equivalent total daily dose taken once daily. Individual dosage adjustments may be necessary.
Elderly: As with other antipsychotics, Seroquel XR should be used with caution in the elderly, especially during the initial dosing period. The rate of dose titration of Seroquel XR may need to be slower, and the daily therapeutic dose lower than that used in younger patients. The mean plasma clearance of quetiapine was reduced by 30% to 50% in elderly patients when compared with younger patients. Elderly patients should be started on 50 mg/day. The dose can be increased in increments of 50 mg/day to an effective dose, depending on the clinical response and tolerance of the individual patient.
In elderly patients with major depressive disorder initial dosing should begin at 50 mg on Day 1-3, the dose can be increased to 100 mg on Day 4, 150 mg on Day 8 and then up to 300 mg depending on clinical response and tolerability (see Pharmacology: Pharmacodynamics under Actions).
Children and adolescents: The safety and efficacy of Seroquel XR have not been evaluated in children and adolescents.
Renal Impairment: Dosage adjustment is not necessary.
Hepatic Impairment: Quetiapine is extensively metabolised by the liver. Therefore, Seroquel XR should be used with caution in patients with known hepatic impairment, especially during the initial dosing period. Patients with hepatic impairment should be started on 50 mg/day. The dose can be increased in increments of 50 mg/day to an effective dose, depending on the clinical response and tolerance of the individual patient.
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