Sertaconazole


Generic Medicine Info
Indications and Dosage
Topical/Cutaneous
Tinea pedis
Adult: As 2% cream: Apply to affected and immediate surrounding areas bid for 4 weeks.
Contraindications
Hypersensitivity.
Special Precautions
Discontinue if irritation or sensitivity develop. Pregnancy and lactation.
Adverse Reactions
Contact dermatitis, dry skin, burning skin, application site reaction, skin tenderness, erythema, pruritus, vesiculation, desquamation, hyperpigmentation.
Patient Counseling Information
Prior to initiation of therapy, confirm diagnosis using KOH or cultures.
MonitoringParameters
Reassess diagnosis if no clinical improvement after 2 wk.
Action
Description: Sertaconazole alters fungal cell wall membrane permeability. It inhibits the CYP450-dependent synthesis of ergosterol.
Pharmacokinetics:
Absorption: Minimal (topical).
Chemical Structure

Chemical Structure Image
Sertaconazole

Source: National Center for Biotechnology Information. PubChem Database. Sertaconazole, CID=65863, https://pubchem.ncbi.nlm.nih.gov/compound/Sertaconazole (accessed on Jan. 23, 2020)

Storage
Store between 20-25°C.
References
Anon. Sertaconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/07/2014.

Buckingham R (ed). Sertaconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/07/2014.

Ertaczo (sertaconazole nitrate) cream (Valeant Pharmaceuticals North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/07/2014.

Ertaczo. U.S. FDA. https://www.fda.gov/. Accessed 15/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Sertaconazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 15/07/2014.

Wickersham RM. Sertaconazole Nitrate - Topical. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 15/07/2014.

Disclaimer: This information is independently developed by MIMS based on Sertaconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in