Sibatam

Sibatam Dosage/Direction for Use

sulbactam

Manufacturer:

Siam Bheasach

Distributor:

Siam Pharmaceutical

Marketer:

Siam Pharmaceutical
The information highlighted (if any) are the most recent updates for this brand.
Full Prescribing Info
Dosage/Direction for Use
Mode of administration: Prior to initiation of therapy, appropriate specimens should be obtained for identification of the causative organism(s) and in vitro susceptibility tests.
Preparation for administration: Reconstituted solutions for IM and IV injection must be clear and colorless to slightly yellow solution.
IM injection: Reconstitute SIBATAM (2 G FOR INJECTION) in vial of drug with 8 mL of sterile water for injection (SWFI) to make clear and colorless to slightly yellow solution for IM injection; which should be injected into large muscles and divided into equal doses of injection. High doses should only be administered for intravenous injection and intravenous infusion. Not recommended for intramuscular injection.
IV Injection: Reconstitute SIBATAM (2 G FOR INJECTION) in vial of drug with 8 mL of sterile water for injection (SWFI) to make clear and colorless to slightly yellow solution for IV injection.
IV Infusion: Reconstitute SIBATAM (2 G FOR INJECTION) in vial of drug with 8 mL of sterile water for injection (SWFI) to make clear and colorless to slightly yellow solution. Add one of the following compatible infusion solutions: 0.9% Normal saline solution (NSS), 5% Dextrose in water (D5W) and Lactate Ringer's solution (LRS).
Stability after reconstitution: SIBATAM (2 G FOR INJECTION) should be used immediately after reconstitution in compatible infusion solutions. If not used immediately, the reconstituted solutions are stable as stated in Tables 1 and 2. (See Tables 1 and 2.)

Click on icon to see table/diagram/image


Click on icon to see table/diagram/image

Recommended dose: Adult dosage: When administered in combination with other beta-lactam antibiotics, the recommended doses are 0.5-1 g Sulbactam every 6, 8 or 12 hours for adults. The maximum daily dose is 4 g, independent of the dose of the combined antibiotics.
A dosage of 6 g per day in divided doses of Sulbactam alone may be considered in multidrug resistant, life threatening Acinetobacter baumannii infections.
Pediatric dosage: When administered in combination with other beta-lactam antibiotics, the recommended dose is 50 mg/kg/day every 6, 8 or 12 hours for pediatric patients. The maximum daily dose is 80 mg/kg/day.
Since Sulbactam's activity in children under one year of age has not been completely clarified yet. Therefore, Sulbactam should be used in this patient population only after a careful benefit-risk assessment.
Dosage in renal function impairment: In patients with impaired renal function, doses and/or frequency of administration should be modified in response to the degree of renal impairment, severity of infection, and susceptibility of causative organism. In case of the pharmacokinetics of Sulbactam and co-administered beta-lactam antibiotics such as ampicillin, these are affected in patients with renal impairment. Dosage should be adjusted in response to the degree of renal impairment.
Dosage in hepatic function impairment: There is no information of dosage adjustment for the use in patients with hepatic function impairment. However, caution is needed when drug is used in patients with hepatic function impairment.
Dosage in geriatric patients: There is no information of dosage adjustment for the use in geriatric patients. However, caution is needed when drug is used in geriatric patients.
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