Symptoms: Limited information is available on the acute toxicity of Sulbactam and co-administered beta-lactam antibiotics, ampicillin, in humans. Overdosage of the drug would be expected to produce manifestations that principally are extensions of the adverse reactions reported with the drug. The fact that high CSF concentrations of beta-lactam antibiotics may cause neurologic effects, including seizures, should be considered.
Treatment: Sulbactam is removed from circulation by hemodialysis. This may enhance elimination of the drug from body if overdosage occur in patients with impaired renal function, but may be unnecessary in patients with normal renal function.