SifrolParkinson's disease Dose escalation: 0.125 mg tid on wk 1, 0.25 mg tid on wk 2, 0.5 mg tid on wk 3. Increase by 0.75 mg at wkly intervals if necessary up to max 4.5 mg/day. Maintenance: 0.375-4.5 mg/day. Patients on levodopa Reduce dose of levodopa. Restless legs syndrome 0.125 mg once daily 2-3 hr before bedtime; may be increased every 4-7 days to max 0.75 mg/day. Sifrol ERParkinson's disease 0.375 mg on wk 1, 0.75 mg on wk 2, 1.5 mg on wk 3. Increase by 0.75 mg at wkly intervals if necessary up to max 4.5 mg/day. Maintenance: 0.375-4.5 mg/day. All doses to be taken once daily.
May be taken with or without food: May be taken w/ meals to minimise GI upset. ER tab: Do not chew/crush/divide.
Special Precautions
Renal impairment. Hallucinations & confusion. May impair ability to drive or operate machinery. Abrupt w/drawal. Severe CV disease. Monitor BP especially at the start of therapy & for melanoma. Childn & adolescent up to 18 yr. Pregnancy & lactation.
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