Sifrol/Sifrol ER

Sifrol/Sifrol ER

pramipexole

Manufacturer:

Boehringer Ingelheim

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Pramipexole
Indications/Uses
Idiopathic Parkinson's disease as monotherapy or in combination w/ levodopa. Symptomatic treatment of idiopathic restless legs syndrome.
Dosage/Direction for Use
Sifrol Parkinson's disease Dose escalation: 0.125 mg tid on wk 1, 0.25 mg tid on wk 2, 0.5 mg tid on wk 3. Increase by 0.75 mg at wkly intervals if necessary up to max 4.5 mg/day. Maintenance: 0.375-4.5 mg/day. Patients on levodopa Reduce dose of levodopa. Restless legs syndrome 0.125 mg once daily 2-3 hr before bedtime; may be increased every 4-7 days to max 0.75 mg/day. Sifrol ER Parkinson's disease 0.375 mg on wk 1, 0.75 mg on wk 2, 1.5 mg on wk 3. Increase by 0.75 mg at wkly intervals if necessary up to max 4.5 mg/day. Maintenance: 0.375-4.5 mg/day. All doses to be taken once daily.
Administration
May be taken with or without food: May be taken w/ meals to minimise GI upset. ER tab: Do not chew/crush/divide.
Special Precautions
Renal impairment. Hallucinations & confusion. May impair ability to drive or operate machinery. Abrupt w/drawal. Severe CV disease. Monitor BP especially at the start of therapy & for melanoma. Childn & adolescent up to 18 yr. Pregnancy & lactation.
Adverse Reactions
Abnormal behaviour eg, binge eating, compulsive shopping, hypersexuality, pathological gambling. Abnormal dreams, amnesia, confusion, constipation, delusion, dizziness, dyskinesia, dyspnoea, fatigue, hallucinations, headache, hyperkinesia, hyperphagia, hypotension, insomnia, libido disorders, nausea, paranoia, peripheral oedema; pneumonia; pruritus, rash & other hypersensitivity; restlessness, somnolence, sudden onset of sleep, syncope, visual disturbance, vomiting, wt changes.
Drug Interactions
Drugs that inhibit active renal tubular secretion of cationic drugs eg, cimetidine, amantadine. Other sedatives, alcohol.
MIMS Class
Antiparkinsonian Drugs
ATC Classification
N04BC05 - pramipexole ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.
Presentation/Packing
Form
Sifrol ER tab 0.375 mg
Packing/Price
3 × 10's
Form
Sifrol ER tab 1.5 mg
Packing/Price
3 × 10's
Form
Sifrol ER tab 3 mg
Packing/Price
3 × 10's
Form
Sifrol tab 0.25 mg
Packing/Price
3 × 10's
Form
Sifrol tab 1 mg
Packing/Price
3 × 10's
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