Simbrinza

Simbrinza

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Per mL Brinzolamide 10 mg, brimonidine tartrate 2 mg (equiv to brimonidine 1.3 mg)
Indications/Uses
Decrease of elevated IOP in adult patients w/ open-angle glaucoma or ocular HTN.
Dosage/Direction for Use
Adult (including the elderly) 1 drop in the affected eye(s) bid.
Contraindications
Hypersensitivity. Patients receiving MAOIs & antidepressants (eg, TCAs & mianserin). Severe renal impairment. Hyperchloraemic acidosis. Neonates & infants <2 yr.
Special Precautions
Narrow-angle glaucoma. Monitor patients wearing contact lens w/ compromised corneas, DM or corneal dystrophies, & w/ frequent or prolonged use. Discontinue if allergic reactions develops. Concomitant use w/ antihypertensives &/or cardiac glycosides. Severe or unstable uncontrolled CV disease. Depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension or thromboangiitis obliterans. Acid-base disturbances. Renal & hepatic impairment. May impair ability to perform tasks requiring mental alertness &/or physical coordination in elderly patients. Avoid contact w/ soft contact lenses. Remove contact lens prior to application & reinsert after at least 15 min. Pregnancy & lactation. Childn 2-17 yr.
Adverse Reactions
Somnolence, dizziness, dysgeusia; eye allergy, keratitis, eye pain, ocular discomfort, blurred vision, abnormal vision, ocular hyperaemia, conjunctival blanching; dry mouth.
Drug Interactions
MAOIs & antidepressants which affect noradrenagic transmission (eg, TCAs & mianserin). Ocular hypotensive response may be blunted by TCAs. Additive or potentiating effect w/ CNS depressants (eg, alcohol, barbiturates, opiates, sedatives or anaesth). Drugs which can affect metabolism & uptake of circulating amines (eg, chlorpromazine, methylphenidate, reserpine, serotonin-norepinephrine reuptake inhibitors). Concomitant use w/ antihypertensives &/or cardiac glycosides; agonists or antagonists of the adrenergic receptor (eg, isoprenaline, prazosin). Acid-base disturbances w/ oral carbonic anhydrase.  Brinzolamide metabolism may be inhibited by CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clotrimazole, ritonavir & troleanclomycin).
ATC Classification
S01EC54 - brinzolamide, combinations ; Belongs to the class of carbonic anhydrase inhibitors. Used in the treatment of glaucoma.
Presentation/Packing
Form
Simbrinza eye drops
Packing/Price
5 mL x 1's
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