SMOFlipid 20%

SMOFlipid 20%

Manufacturer:

Fresenius Kabi

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 1,000 mL Refined soya bean oil 60 g, medium-chain triglycerides 60 g, refined olive oil 50 g, fish oil (rich in omega-3 acids) 30 g. Total energy: 2,000 kCal/L; osmolality: Approx 380 mOsmol/kg·H2O
Indications/Uses
Supply of energy & essential fatty acids & omega-3 fatty acids as part of a parenteral nutrition regimen when oral or enteral nutrition is impossible, insufficient or contraindicated.
Dosage/Direction for Use
Adult 1-2 g fat/kg body wt/day corresponding to 5-10 mL/kg body wt/day infused at 0.125 g fat/kg body wt/hr corresponding to 0.63 mL SMOFlipid/kg body wt/hr. Max: 0.15 g fat/kg body wt/hr corresponding to 0.75 mL SMOFlipid/kg body wt/hr. Childn Max daily dose: 3 g fat/kg body wt/day corresponding to 15 mL SMOFlipid/kg body wt/day, gradually increased during 1st wk of administration. Infusion rate should not exceed 0.15 g fat/kg body wt/hr. Neonate & infant Initially 0.5-1 g fat/kg body wt/day followed by successive increase by 0.5-1 g fat/kg body wt/day up to 3 g fat/kg body wt/day. Max daily dose: 3 g fat/kg body wt/day corresponding to 15 mL SMOFlipid/kg body wt/day. Infusion rate should not exceed 0.125 g fat/kg body wt/hr. Premature & low birth wt neonate Infused continuously over about 24 hr.
Contraindications
Hypersensitivity to fish, egg, soy or peanut protein. Severe hyperlipidemia, liver insufficiency, blood coagulation disorders or renal insufficiency w/o access to hemofiltration or dialysis. Acute shock, unstable conditions (eg, severe post-traumatic conditions, uncomplicated DM, acute MI, stroke, embolism, metabolic acidosis, severe sepsis, hypotonic dehydration). Acute pulmonary oedema, hyperhydration, decompensated cardiac insufficiency.
Special Precautions
Impaired lipid metabolism; DM; renal failure. Monitor for metabolic acidosis.
Drug Interactions
Heparin.
ATC Classification
V06DX - Other combinations of nutrients ; Used as general nutrients.
Presentation/Packing
Form
SMOFlipid 20% emulsion for infusion
Packing/Price
100 mL x 1's;250 mL x 1's
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