Instructions for Use and Handling: Preparation of Solutions: To prepare solutions for IV infusion, 1st reconstitute Solu-Medrol as directed. Therapy may be initiated by administering Solu-Medrol IV over a period of at least 5 min (eg, doses up to 250 mg) to at least 30 min (eg, doses of ≥250 mg). Subsequent doses may be withdrawn and administered similarly. If desired, the medication may be administered in dilute solutions by admixing the reconstituted product with dextrose 5% in water, normal saline, dextrose 5% in 0.45% or 0.9% sodium chloride; the resulting solutions are physically and chemically stable for 48 hrs.
Directions for using Act-O-Vial 2-Compartment Vial: Press down on plastic activator to force diluent into the lower compartment. Gently agitate to effect solution. Use solution within 48 hrs. Remove plastic tab covering center of stopper. Sterilize top of plunger-stopper with a suitable germicide. Insert needle through center of plunger-stopper until tip is just visible. Invert vial and withdraw dose.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.