Other NSAIDs and aspirin: Avoid concomitant use of ibuprofen with aspirin or other NSAIDs since it may increase the risk of the adverse GI effects.
Anticoagulants and thrombolytic agents: NSAIDs including ibuprofen may increase the effects of anticoagulants, such as warfarin and thrombolytic agents.
Lithium: serum lithium levels may be increase, closely monitored for signs of lithium toxicity.
ACE Inhibitors and Angiotensin II Receptor Antagonist: NSAIDs including ibuprofen may decrease the antihypertensive effect of these drugs (such as enalapril and losartan).
Diuretics: NSAIDs including ibuprofen may decrease the diuretic effect. Closely monitored for signs of renal failure and for efficacy of diuretics if use in concomitant.
Methotrexate: Because of the risk of increase methotrexate toxicity, caution is advice if methotrexate and NSAIDs are administered concomitantly.