Overdose: The most frequent manifestations of ibuprofen overdosage reportedly are abdominal pain, nausea, vomiting, lethargy, and drowsiness. In addition, other adverse effects, including headache, tinnitus, CNS depression, seizures, hypotension, bradycardia, tachycardia, and atrial fibrillation, may occur. Metabolic acidosis, coma, acute renal failure, hyperkalemia, apnea (mainly in young children), respiratory depression, and respiratory failure have been reported rarely.
Treatment: Treatment of acute toxicity associated with ibuprofen overdosage mainly is supportive. When acute overdosage of ibuprofen occurs, the stomach should be emptied by inducing emesis with syrup of ipecac or by lavage. Administration of activated charcoal may be useful in reducing absorption and reabsorption of ibuprofen.