Conivaptan, floctafenine, methacholine. May increase levels/effects of direct-acting α- or β-agonists, α1
-agonists, amifostine, antihypertensives, antipsychotic agents (eg, phenothiazines), bupivacaine, cardiac glycosides, cholinergic agonists, ergot derivatives, fingolimod, hypotensive agents, insulin, systemic & topical lidocaine, mepivacaine, methacholine, midodrine, rituximab, sulfonylureas. Increased level/effects by acetylcholinesterase inhibitors, α2
-agonists, antimalarial (eg, aminoquinolines), amiodarone, anilidopiperidine, opioids, antipsychotic agents (eg, phenothiazines), Ca channel blockers (eg, dihydropyridine, nondihydropyridine), conivaptan, enzyme CYP3A4 inhibitors (moderate-strong), dasatinib, diazoxide, dipyridamole, disopyramide, dronedarone, floctafenine, herbs, ivacaftor, MAOIs, mifepristone, pentoxyfylline, phosphodiesterase 5 inhibitors, propafenone, prostacyclin analogues, quinidine, reserpine. May decrease levels/effects of β2
-agonists & theophylline derivatives. Decreased levels/effects w/ barbiturates, strong CYP3A4 inducers, deferasirox, herbs, methylphenidate, NSAIDs, peginterferon α-2b, rifamycin derivatives, tocilizumab, yohimbine. Avoid dong quai, ephedra, ginseng, garlic. Sopalol 5: May increase levels/effects of oral anti-diabetic medicines, mefloquine. Increased level/effects by flecainide, phenytoin, topical β-blockers, anaesth agents, antihypertensive agents & other medicines w/ BP-lowering potential (eg, TCAs, barbiturates, phenothiazines). Decrease levels/effects w/ St. John's wort.