Sopalol 2.5/Sopalol 5

Sopalol 2.5/Sopalol 5 Special Precautions

bisoprolol

Manufacturer:

Intas Pharmaceuticals

Distributor:

Berlin Pharm
Full Prescribing Info
Special Precautions
Sopalol 2.5: Consider pre-existing conditions such as sick sinus syndrome before initiating.
Use with caution in the following patients: Heart failure; use gradual and careful titration; monitor for symptoms of congestive heart failure.
Myasthenia gravis, psychiatric disease (may cause CNS depression), bronchospastic disease, undergoing anesthesia and in those with impaired hepatic function.
Bradycardia may be observed more frequently in elderly patients (>65 years of age), dosage reductions may be necessary.
Beta-blocker therapy should not be withdrawn abruptly (particularly in patients with CAD) but gradually tapered to avoid acute tachycardia, hypertension and/or ischemia.
Chronic beta-blocker therapy should not be routinely withdrawn prior to major surgery.
Can precipitate or aggravate symptoms of arterial insufficiency in patients with PVD and Raynaud's disease, use with caution and monitor for progression of arterial obstruction.
Concurrent use of digoxin, verapamil, or diltiazem, bradycardia or heart block may occur.
Receiving inhaled anesthetic agents known to depress myocardial contractility.
Bisoprolol, with beta1-selectivity may be used cautiously in bronchospastic disease with close monitoring.
Diabetes because it can mask prominent hypoglycemic symptoms.
May mask signs of hyperthyroidism (e.g. tachycardia) use caution if hyperthyroidism is suspected, abrupt withdrawal may precipitate thyroid storm.
Dosage adjustment is required in patients with significant hepatic or renal dysfunction.
Adequate alpha-blockade is required prior to use of any beta-blocker for patients with untreated pheochromocytoma. May induce or exacerbate psoriasis.
Use caution with history of severe anaphylaxis to allergens; patients taking beta-blockers may become more sensitive to repeated challenges. Treatment of anaphylaxis (e.g. epinephrine) in patients taking beta-blockers may be ineffective or promote undesirable effects.
Sopalol 5: Before initiating use of bisoprolol in patients, physicians must ensure that the patient is not pre-existing conditions such as sick sinus syndrome.
Using bisoprolol in patients with heart failure must start with gradually increasing dosages as recommended (titration phase) and constantly monitor congestive heart failure symptom, particularly, the heart failure patients with restrictive cardiomyopathy, congenital heart disease, haemodynamically significant organic valvular disease, or insulin dependent diabetes mellitus (Type 1), severely impaired hepatic/renal function because of no therapeutic experience of bisoprolol treatment in those patients.
Bradycardia may be observed more frequently in elderly patients (>65 years of age), dosage reductions may be necessary and should not be withdrawn abruptly. In patients with CAD (angina pectoris), use gradual and careful titration to avoid acute tachycardia, hypertension and/or ischemia. In case of no withdrawal of bisoprolol before anesthesia, anesthetist should gradually reduce bisoprolol dose and stop the drug at least 48 hours before anesthesia.
Cautiously using bisoprolol in patients with bronchial asthma or chronic obstructive lung diseases (COLD) or emphysema, because asthma symptoms may occur. Therefore, the dose of beta2-agonists (bronchodilators) may need to be increasingly adjusted be increased.
Diabetes mellitus patients taking bisoprolol and poor blood sugar control may in danger of hypoglycaemia without sign which can be masked by disoprolol.
Bisoprolol may mask signs of hyperthyroidism e.g. tachycardia, abrupt withdrawal of bisoprolol may precipitate thyroid storm.
For patients with untreated pheochromocytoma, adequate alpha-blockade is required prior to use of any beta-blocker.
Bisoprolol may induce or exacerbate psoriasis.
This drug causes artery constriction, it should not be used in patients with narrow peripheral arterial disease or occlusive, or Raynaud's disease.
Dosage adjustment is required in patients with significant hepatic or renal dysfunction.
Patient are thought necessary to withdraw bisoprolol before anesthesia, this should be done gradually and completed about 48 hours.
Concurrent use of digoxin, verapamil, or diltiazem may cause bradycardia or heart block may occur.
In patients taking beta-blocker and with allergy reaction anaphylaxis as epinepharine may be used for treatment but can increase more severity.
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