Stavir

Stavir

stavudine

Manufacturer:

GPO

Distributor:

GPO
Concise Prescribing Info
Contents
Stavudine
Indications/Uses
Cap: HIV-infection in combination w/ other antiretrovirals. HIV-infected patients who are intolerant or have not responded to zidovudine therapy. Oral soln: HIV-1 infection in combination w/ other antiretrovirals in adult & ped patients.
Dosage/Direction for Use
Cap Adult CrCl >50 mL/min weighing ≥60 kg 40 mg every 12 hr, <60 kg 30 mg every 12 hr; CrCl 26-50 mL/min weighing ≥60 kg 20 mg every 12 hr, <60 kg 15 mg every 12 hr; CrCl 10-25 mL/min weighing ≥60 kg 20 mg every 24 hr, <60 kg 15 mg every 24 hr. Childn ≥30 kg 30 mg every 12 hr, <30 kg 1 mg/kg every 12 hr. Oral soln Childn weighing ≥30 kg 30 mg every 12 hr, <30 kg 1 mg/kg every 12 hr.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Hepatic or renal function impairment. Pregnancy & lactation. History of peripheral neuropathy. Cap: Monitor for neuropathy development. Oral soln: Risk of lactic acidosis. Increased risk of pancreatitis. Concomitant use w/ zidovudine.
Adverse Reactions
Cap: Hepatitis, pancreatitis, peripheral neuropathy; arthralgia, myalgia, headache, chills or fever, infections, abdominal & back pain, flu syndrome, asthenia, anorexia, wt loss, dyspepsia, lymphadenopathy, anemia, insomnia, depression, anxiety, nervousness, dizziness, rhinitis, cough, pharyngitis, resp disorder, dyspnea, nausea, vomiting, diarrhea, rash, pruritus, sweating & fungal dermatitis. Oral soln: Lactic acidosis/severe hepatitis w/ steatosis, pancreatitis, peripheral neuropathy; generalized fatigue, nausea, vomiting, abdominal pain, tachypnea, dyspnea, motor weakness.
MIMS Class
ATC Classification
J05AF04 - stavudine ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Presentation/Packing
Form
Stavir cap 15 mg
Packing/Price
60's
Form
Stavir cap 30 mg
Packing/Price
60's
Form
Stavir oral soln 5 mg/mL
Packing/Price
60 mL x 1's
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