Each 100 mL contains Sterile water for injection 100 mL.
Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Average normal adult daily requirement ranges from two to three liters (1 to 1.5 liters each for insensible water loss by perspiration and urine production). Water balance is maintained by various regulatory mechanisms. Water distribution depends primarily on the concentration of electrolytes in the body compartments and sodium (Na+) plays a major role in maintaining physiologic equilibrium.
SWI T.O. is indicated for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.
The recommended dosage is prescribed by the doctor and the calculation of the dosage of SWI T.O. is dependent upon the dissolving drug, age, weight and clinical condition of the patient as well as laboratory determinations.
Some additives may be incompatible. Consult with pharmacist. When performing admixture or dilution, use aseptic techniques. Mix thoroughly and use promptly. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute.
Mode of Administration: This solution is for injection use only after admixture or dilution. Do not inject until made approximately isotonic by addition of appropriate solute.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
The symptom depends on the dosage of administered drug. If overdose symptom has occurred, stop receiving that drug. The symptomatic or supportive treatment is recommended.
Overdosage (hypotonic expension) is a function an increase in fluid intake over fluid output, and occurs when the increase in the volume of body fluids is due to water alone. Overdosage may occur in patients who receive large quantities of electrolyte-free water to replace abnormal excessive fluid losses, in patients whose renal tolerance to water loads is exceeded, or in patients who retain water postoperatively in response to stress.
Manifestations of water intoxication are behavioral changes (confusion apathy, disorientation and attendant hyponatremia), central nervous system disturbances (weakness, muscle twitching, headaches, nausea, vomiting, convulsions) and weight gain.
Treatment consists of withholding fluids until excessive water is excreted. In severe hyponatremia it may be necessary to cautiously administer hypertonic saline to increase extracellular osmotic pressure and excretion of excess water by the kidney.
The contraindication depends on the drug to be administered.
Use only if solution is clear and container and seals are intact. Intravenous administration of SWI T.O. without a solute may result in hemolysis. Do not inject until made approximately isotonic by addition of an appropriate solute, due to the possibility of hemolysis.
To minimize the risk of possible incompatibilities arising from the mixing of additives that may be prescribed, the final infuscate should be inspected for cloudiness or precipitation immediately after mixing, prior to administration and periodically during administration.
Refer to the package insert of the solute used.
Reactions which may occur because of the solution or the technique of administration include febrile response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasations.
The physician should also be alert to the possibility of adverse reactions to drug additives. Prescribing information for drug additives to be administered in this manner should be consulted. If an adverse reaction does occur, discontinue the injection, evaluate the patient, institute appropriate therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
Incompatability or inappropriate solubility with the substance or drug being reconstituted or prepared may be occurred. Refer to the package insert of the solute used. Before reconstituted of drug should be prescribed by the doctor or consulted to the pharmacist.
V07AB - Solvents and diluting agents, incl. irrigating solutions ; Used as solvents and diluting agents, including irrigating solutions.
Inj (amp) (clear colorless, sterile solution) 5 mL x 25 x 4's. 10 mL x 25 x 4's.