Generic Medicine Info
Indications and Dosage
Plaque psoriasis
Adult: As 4 mcg/g ointment or lotion: Apply sparingly onto affected area(s) once daily, preferably at bedtime. Max dose: 10 g ointment or 10 mL daily; 280 mcg per week (e.g. 30 mL lotion + 40 g ointment).
Hypercalcaemia, Ca metabolism disorder.
Special Precautions
Patient with generalised pustular or erythrodermic exfoliative psoriasis. Renal impairment. Pregnancy and lactation. Combined treatment with UV radiation.
Adverse Reactions
Significant: Hypercalcaemia.
Nervous system disorders: Paraesthesia.
Skin and subcutaneous tissue disorders: Skin irritation, itching, burning, erythema, contact dermatitis.
Patient Counseling Information
Avoid contact with eyes.
Monitoring Parameters
Monitor serum Ca level.
Drug Interactions
May increase the risk of hypercalcaemia with thiazide diuretics and vitamin D preparations. Increased therapeutic effect and shorten UV radiation period.
Description: Tacalcitol, a synthetic vitamin D3 derivative, is an antipsoriatic agent. It binds to vitamin D receptors to induce differentiation and inhibits hyper-proliferation of keratinocytes.
Synonym: tacalcitolum.
Absorption: 0.5% absorbed through psoriatic skin.
Distribution: Completely bound to plasma proteins.
Excretion: Mainly via urine.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Tacalcitol, CID=5283734, https://pubchem.ncbi.nlm.nih.gov/compound/Tacalcitol (accessed on Jan. 23, 2020)

Store below 25°C.
MIMS Class
Psoriasis, Seborrhea & Ichthyosis Preparations
ATC Classification
D05AX04 - tacalcitol ; Belongs to the class of other antipsoriatics for topical use.
Anon. Causes of Hypercalcemia. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 09/05/2018.

Buckingham R (ed). Tacalcitol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2018.

Joint Formulary Committee. Tacalcitol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 09/05/2018.

Disclaimer: This information is independently developed by MIMS based on Tacalcitol from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by MIMS.com
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