Concise Prescribing Info
Treatment of infections caused by susceptible gm +ve bacteria, including those resistant to other antibiotics (eg, methicillin & cephalosporins): Endocarditis, septicaemia; bone & joint, skin & soft tissue, resp infections; UTI, peritonitis associated w/ chronic ambulatory peritoneal dialysis. Infections in patients who are allergic to penicillins or cephalosporins. Antibiotic-associated diarrhea caused by Clostridium difficile.
Dosage/Direction for Use
Adult & elderly Moderate infections (skin & soft tissue, lower resp tract infections; UTI) Loading dose: Single 400 mg IV on 1st day. Maintenance dose: Single 200 mg IV or IM daily. Severe infections (joint & bone infection, septicaemia, endocarditis) Loading dose: 400 mg IV 12 hrly for the 1st 3 doses. Maintenance dose: Single 400 mg IV or IM daily. In some clinical situations eg, infected, severely burned patients or Staph aureus endocarditis, unit maintenance doses up to 12 mg/kg may be required. (Standard doses of 200 mg equate to mean doses of 3 mg/kg.) Patients >85 kg Adapt the dosage to the wt following the same therapeutic schedule; moderate infection 3 mg/kg, severe infection 6 mg/kg. Antibiotic-associated diarrhea caused by Clostridium difficile 200 mg orally twice daily. Childn ≥2 mth-16 yr Most gm +ve infections Loading regimen of three 12-hrly doses of 10 mg/kg IV, followed by a maintenance dose of 6 mg/kg IV or IM once daily. Severe infections & infections in the neutropenic patient Loading regimen of three 12-hrly doses of 10 mg/kg IV, followed by 10 mg/kg IV once daily. Childn <2 mth Single loading dose of 16 mg/kg IV on 1st day, followed by 8 mg/kg IV once daily. To be infused over 30 min.
Special Precautions
Known hypersensitivity to vancomycin. Hearing, hematologic, hepatic & renal toxicities, renal insufficiency & prolonged treatment, periodic hematological studies are advised. Renal & auditory tests should be done on patients who require concurrent use of neurotoxic &/or nephrotoxic drugs, superinfection.
Adverse Reactions
Local reactions, hypersensitivity, infusion-related events, nausea, dizziness, headache, eosinophilia, leukopenia.
MIMS Class
ATC Classification
J01XA02 - teicoplanin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections.
Targocid powd for inj 200 mg
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