Pharmacology: Pharmacodynamics: Mechanism of action: Vitamin C (ascorbic acid) is a water-soluble vitamin with antioxidant properties. The vitamin is an essential coenzyme for collagen formation, tissue repair, and synthesis of lipids and proteins. It acts both as a reducing agent and as an antioxidant and is necessary for many physiological functions (e.g., metabolism of iron and folic acid, resistantace to infection, preservation of blood vessel integrity).
Pharmacokinetics: Ascorbic acid is normally present in both plasma and cells. The absorbed vitamin is ubiquitous in all body tissue. The highest concentration are found in granular tissue, the lowest in muscle and stored fat. A major route of metabolism of ascorbic acid involves its conversion to urinary oxalate, presumably through intermediate formation of its oxidized product, dehydroascorbic acid. Ascorbic acid is partially destroy and partially excreted by the body. There is a renal threshold for vitamin C; the vitamin is excreted by kidney in large amounts only when the plasma concentration exceeds this threshold, which is approximately 1.4 mg/100 ml.