Temozolomide - oral

Patient Medicine Information
Why do I need this medicine?
Temozolomide is used to treat cancer of the brain.

This medicine reduces the size of the tumour by stopping cancer cells from growing.

It may be used on its own or together with other medicines or radiotherapy treatment.
How do I take this medicine?
Take Temozolomide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine on an empty stomach, at least 1 hour before your meal. Swallow it whole. Do not open or chew. Try to take it at the same time each day.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the type and severity of your condition.

Take Temozolomide at regular intervals. Complete the entire course of medicine.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Temozolomide or other similar medicines such as dacarbazine.
What should I take note of while using this medicine?
Inform your doctor if you have the following conditions:
  • liver disease
  • kidney disease
  • blood disorder such as low platelet, red or white blood cell count
It is important that you do not get pregnant or father a child while being treated with Temozolomide. You may wish to discuss birth control methods with your doctor or pharmacist. Avoid pregnancy or fathering a child for at least 6 months after you stop taking this medicine.

Let your doctor know if you are breastfeeding.

Be sure to check with your doctor or pharmacist before giving this medicine to a child or an elderly as they are more sensitive to the side effects.

Inform your doctor if you have been recently vaccinated. Do not receive any vaccinations without first asking your doctor.

Wear gloves when handling this medicine to minimise any skin contact. If contact with broken tablets or capsules occurs, wash your hands immediately and thoroughly.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. You need to have routine blood tests (e.g. complete blood count, liver function tests) while you are being treated with Temozolomide. Your doctor will advise you about how often you need to have these tests.
What side effects could I experience?
Temozolomide may cause dizziness, tiredness, and weakness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects may include any of the following: headache, nausea, vomiting, constipation, diarrhoea, loss of appetite and hair loss.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swollen mouth or eyes
  • signs and symptoms of liver problems e.g. yellowing of the skin or eyes, stomach pain, tiredness, nausea or vomiting
  • signs of infection e.g. fever, chills, sore throat, mouth sore
  • unusual bleeding or bruising 
  • seizures
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Inform your doctor and pharmacist if you are taking medicines for epilepsy (fits or seizures) e.g. valproic acid.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol.
How should I store this medicine?
Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As Temozolomide is an anti-cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the normal household waste.
This information is independently developed by MIMS based on temozolomide - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in