HIV-1 infection in combination w/ other antiretroviral agents eg, NNRTIs or PIs. Pre-exposure prophylaxis for prevention of HIV-1 infection.
Dosage/Direction for Use
Adult 1 tab once daily. HIV-1 Infection 1 tab once daily. Pre-exposure prophylaxis (PrEP) 1 tab once daily.
May be taken with or without food.
Lactic acidosis & severe hepatomegaly w/ steatosis. Avoid concomitant use w/ nephrotoxic agents. Co-infection w/ hepatitis B or C. Perform initial test for the presence of chronic HBV prior to antiretroviral therapy. Immune reconstitution syndrome. Lipodystrophy. Renal impairment. Monitor bone in patients w/ history of pathologic bone fracture. Carefully monitor patients on a therapy utilizing a triple nucleoside-only regimen. Childn <18 yr. Elderly. Pregnancy & lactation.