Terbutaline Sulfate GPO

Terbutaline Sulfate GPO

terbutaline

Manufacturer:

GPO

Distributor:

GPO
Full Prescribing Info
Contents
Terbutaline sulfate.
Description
Each mL contains: Terbutaline sulfate 0.50 mg.
Action
Terbutaline sulfate is a synthetic adrenergic bronchodilator. This drug is a β-adrenergic stimulant which has more selective effect on the β2-receptors of the bronchial, vascular, and uterine smooth muscles than on the β1-receptors of the heart.
Terbutaline sulfate is well absorbed following subcutaneous injection. It has an onset of action within 15 minutes, peak effects occur within 0.5-1 hour, and the duration of action ranges from 1.5-4 hours. The drug is partially metabolized in the liver, mainly to the inactive sulfate conjugate. Following injection, about 60% of a dose is excreted in the urine as unchanged drug, up to 3% is excreted in feces via the bile, and the remainder is excreted in urine as the conjugate. Terbutaline crosses the placenta and appears in breast milk.
Indications/Uses
As a bronchodilator, for the symptomatic treatment of bronchospasm associated with bronchial asthma, bronchitis, and emphysema; and bronchospasm during anaesthesia.
For the management of premature labor.
Dosage/Direction for Use
Adults: Bronchodilator- Subcutaneous, 0.25 mg, repeated after 15-30 minutes if necessary; a total dose of 0.5 mg should not be exceeded within a 4-hour period.
Contraindications
In patients who are hypersensitive to sympathomimetic agents, children under 12 years, pregnancy & lactating women.
Special Precautions
It should be used with caution in patients with diabetes mellitus, hypertension, hyperthyroidism, a history of seizures, or cardiac disease.
Caution is recommended when concomitantly used with other drugs such as theophylline derivatives (e.g. aminophylline), MAO inhibitors, tricyclic antidepressants, β-adrenergic blocking agents (e.g. propranolol).
Adverse Reactions
The most common side-effects are an increase in heart rate, changes in blood pressure, nervousness, tremor, palpitation, and dizziness.
Storage
Store below 25°C, protect from light.
ATC Classification
R03CC03 - terbutaline ; Belongs to the class of adrenergics for systemic use, selective beta-2-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.
Presentation/Packing
Inj (amp) 0.5 mg/mL x 50's x 1's.
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