TheraCIM Description



Innogene Kalbiotech


Alliance Pharma
Full Prescribing Info
Each 10 mL also contains the following excipients: Dibasic sodium phosphate 18 mg, monobasic sodium phosphate 4.5 mg, sodium chloride 86 mg, polysorbate 80 2 mg and water for injection to make 10 mL.
TheraCIM is a recombinant humanized monoclonal antibody that binds to the extracellular domain of human epidermal growth factor receptor (EGFR). The humanized antibody (IgG1) was obtained by transplanting the complementarity determining regions (CDRs) of the murine IgG2a monoclonal antibody (ior egf/r3) to a human framework assisted by computer modeling. A reshaped antibody was constructed using the light and heavy chains (REI and Eu, respectively) as human immunoglobulin framework for CDR-grafting. TheraCIM is produced through mammalian cell culture of nonsecreting NSO cells and has a molecular weight of 151 KD.
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