Thymoglobuline

Thymoglobuline

Manufacturer:

Sanofi-Aventis

Distributor:

DKSH
Concise Prescribing Info
Contents
Rabbit anti-human thymocyte Ig
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Prophylaxis of acute rejection 1-1.5 mg/kg/day for 2-9 days after transplantation of kidney, pancreas or liver & for 2-5 days after heart transplantation, corresponding to a cumulative dose of 2-7.5 mg/kg in heart transplant & 2-13.5 mg/kg for other organs. Treatment of acute rejection 1.5 mg/kg/day for 3-14 days, corresponding to a cumulative dose of 4.5-21 mg/kg. Aplastic anemia 2.5-3.5 mg/kg/day for 5 consecutive days, corresponding to cumulative dose of 12.5-17.5 mg/kg. Prophylaxis of acute & chronic GvHD 2.5 mg/kg/day from day -4 to day -2 or -1, corresponding to cumulative dose of 7.5-10 mg/kg. Treatment of steroid-resistant acute GvHD 2-5 mg/kg/day for 5 days.
Contraindications
Acute infections contraindicating any additional immunosuppression. Known allergy to rabbit proteins.
Special Precautions
Pregnancy & lactation, patients who have already received rabbit Ig. In aplastic anemia, immunosuppressive treatment contributes to the risk of infection.
Adverse Reactions
Rigors, fever, erythema, pruritic skin eruptions. Thrombocytopenia, neutropenia, serum sickness. Anaphylactic reaction.
Drug Interactions
Cyclosporine, tacrolimus, mycophenolate mofetil, live attenuated vaccine, other rabbit Ig.
MIMS Class
ATC Classification
L04AA04 - antithymocyte immunoglobulin (rabbit) ; Belongs to the class of selective immunosuppressive agents. Used to induce immunosuppression.
Presentation/Packing
Form
Thymoglobuline inj 25 mg
Packing/Price
(freeze-dried) 1's
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