Timoptol

Timoptol

timolol

Manufacturer:

Santen

Distributor:

DKLL
Concise Prescribing Info
Contents
Timolol maleate
Indications/Uses
Reduction of elevated IOP in ocular HTN, chronic open-angle glaucoma, aphakic patients w/ glaucoma, secondary glaucoma, narrow angle & history of spontaneous or iatrogenically induced narrow-angle closure in the opposite eye in whom reduction of IOP is necessary. Concomitant therapy in patients w/ ped glaucoma who are inadequately controlled w/ other antiglaucoma therapy.
Dosage/Direction for Use
Adult Initially 1 drop of 0.25% in the affected eye(s) bid. If clinical response is not adequate, dosage may be changed to 1 drop of 0.5% soln bid. If needed, concomitant therapy w/ other agent(s) for lowering IOP may be given w/ Timoptol. Monitor IOP after approx 4 wk of treatment, change to once daily therapy as appropriate. To transfer from other topical ophth β-blockers: Discontinue the agent after proper dosing for 1 day & begin treatment on the following day. To transfer from single antiglaucoma agent, other than a topical ophth β-blocker: Continue agent already being used & add 1 drop of 0.25% Timoptol in each affected eye bid. On the following day, discontinue the previously used antiglaucoma agent & continue w/ Timoptol. Childn Initially 1 drop of 0.25% in the affected eye(s) 12 hrly, in addition to other antiglaucoma medication. Dosage may be increased to 1 drop of 0.5% soln 12 hrly, if necessary.
Contraindications
Hypersensitivity. Reactive airway disease, bronchial asthma or history of bronchial asthma or severe COPD. Sinus bradycardia, sino-atrial block, 2nd & 3rd degree AV block, overt cardiac failure, cardiogenic shock.
Special Precautions
Adequately control cardiac failure prior to initial therapy. Patients w/ history of CV disease should be monitored for signs of deterioration & pulse rates. 1st degree heart block. Asthma. Mild or moderate COPD. Severe peripheral circulatory disturbance or disorders eg, severe forms of Raynaud's disease or syndrome. Spontaneous hypoglycemia or diabetics receiving insulin or oral hypoglycemic agents. May mask clinical signs of hyperthyroidism eg, tachycardia. Avoid abrupt w/drawal in patients suspected of developing thyrotoxicosis. Surgical anesth. Use w/ a miotic to reduce elevated IOP in angle-closure glaucoma. Choroidal detachment. Remove soft contact lenses prior to administration; reinsert after 15 min. History of atopy or history of severe anaphylactic reaction to a variety of allergens. Pregnancy & lactation. Premature infants or neonates.
Adverse Reactions
Ocular irritation including burning & stinging, conjunctivitis, blepharitis, keratitis, decreased corneal sensitivity, & dry eyes. Visual disturbances, including refractive changes (due to w/drawal of miotic therapy in some cases), diplopia, ptosis, choroidal detachment following filtration surgery, tinnitus; bradycardia, arrhythmia, hypotension, syncope, heart block, CVA, cerebral ischemia, CHF, palpitation, cardiac arrest, edema, claudication, Raynaud's phenomenon, cold hands & feet; bronchospasm (predominantly in patients w/ preexisting bronchospastic disease), resp failure, dyspnea, cough; headache, asthenia, fatigue, chest pain; alopecia, psoriasiform rash or exacerbation of psoriasis; signs & symptoms of allergic reactions including anaphylaxis, angioedema, urticaria, localized & generalized rash; dizziness, depression, insomnia, nightmares, memory loss, increase in signs & symptoms of myasthenia gravis, paresthesia; nausea, diarrhea, dyspepsia, dry mouth, abdominal pain; decreased libido, Peyronie's disease, sexual dysfunction; SLE; myalgia.
Drug Interactions
Potentiated systemic β-blockade w/ CYP2D6 inhibitors eg, quinidine, SSRIs. Potential additive effects, hypotension, marked bradycardia w/ oral Ca entry blocker, catecholamine-depleting drugs, antiarrhythmics, parasympathomimetics or β-adrenergic blockers. May exacerbate rebound HTN w/ clonidine.
ATC Classification
S01ED01 - timolol ; Belongs to the class of beta blocking agents. Used in the treatment of glaucoma.
Presentation/Packing
Form
Timoptol ophth soln 0.5 %
Packing/Price
5 mL x 1's
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