T. O. Chemicals


T. O. Chemicals
Concise Prescribing Info
Essential HTN, CHD, symptomatic stable chronic heart failure, left ventricular dysfunction following acute MI.
Dosage/Direction for Use
Essential HTN Initially 12.5 mg once daily for first 2 days. Maintenance: 25 mg once daily. May be increased at 2-wk intervals to total daily dose: 50 mg once daily or in divided doses. CHD Initially 12.5 mg bid for first 2 days. Maintenance: 25 mg bid. May be increased at 2-wk intervals to total daily dose: 100 mg in divided doses. Symptomatic, stable chronic heart failure Initially 3.125 mg bid for 2 wk, may be increased at 2-wk intervals to 6.25 mg bid followed by 12.5 mg bid & 25 mg bid thereafter. Patient >85 kg Max: 50 mg bid, <85 kg Max: 25 mg bid. If discontinued for >1 wk, recommence at 3.125 mg bid & titrate dose accordingly. Left ventricular dysfunction following acute MI Initially 6.25 mg bid, may be increased to 12.5 mg bid after 3-10 days & 25 mg bid thereafter.
Should be taken with food.
Unstable/decompensated heart failure, liver dysfunction, 2nd- & 3rd-degree AV block, severe bradycardia, sick sinus syndrome, severe hypotension, cardiogenic shock, history of bronchospasm or asthma.
Special Precautions
Concomitant digitalis glycosides as both drugs slow AV conduction. Renal function in chronic heart failure; COPD.
Adverse Reactions
Dizziness, headache, fatigue bradycardia, postural hypotension, hypotension, asthma/dyspnea, GI upset, manifestation of latent DM.
Drug Interactions
Digoxin, insulin or oral hypoglycemics, rifampicin, clonidine, catecholamine-depleting agents eg, reserpine, MAOI, cyclosporin, verapamil, diltiazem or other antiarrhythmics.
MIMS Class
ATC Classification
C07AG02 - carvedilol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Tocarlol tab 25 mg
10 × 10's
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