Very common effects (≥ 1:10): Nervous system disorders: Dizziness, somnolence.
Common (≥ 1:100 to <1:10): Metabolism and nutrition disorders: Appetite increased.
Psychiatric disorders: Confusion, disorientation, irritability, euphoric mood, libido decreased, insomnia.
Nervous system disorders: Ataxia, coordination abnormal, balance disorder, amnesia, disturbance in attention, memory impairment, tremor, dysarthria, paraesthesia, sedation, lethargy.
Eye disorders: Vision blurred, diplopia.
Ear and labyrinth disorders: Vertigo.
Gastrointestinal disorders: Vomiting, abdominal distension, constipation, dry mouth, flatulence.
Reproductive system and breast disorders: Erectile dysfunction.
General disorders and administration site conditions: Oedema peripheral, oedema, gait abnormal, feeling drunk, fatigue.
Investigations: Weight increased.
Uncommon (≥1:1,000 to < 1:100): Infections and infestations: Nasopharyngitis.
Metabolism and nutrition disorders: Anorexia.
Psychiatric disorders: Depersonalisation, anorgasmia, restlessness, agitation, depression, mood swings, depressed mood, word finding difficulty, hallucination, abnormal dreams, libido increased, panic attack, apathy.
Nervous system disorders: Cognitive disorder, hypoaesthesia, nystagmus, speech disorder, myoclonus, hyporeflexia, dyskinesia, psychomotor hyperactivity, postural dizziness, hyperaesthesia, ageusia, burning sensation, intention tremor, stupor, syncope.
Eye disorders: Visual disturbance, visual field defect, dry eye, eye swelling, visual acuity reduced, eye pain, asthenopia, lacrimation increased.
Ear and labyrinth disorders: Hyperacusis.
Cardiac disorders: Atrioventricular block first degree, tachycardia.
Vascular disorders: Hypotension, hypertension, flushing, hot flushes, peripheral coldness.
Respiratory, thoracic and mediastinal disorders: Dyspnoea, cough, nasal dryness.
Gastrointestinal disorders: Salivary hypersecretion, gastrooesophageal reflux disease, oral hypoaesthesia.
Skin and subcutaneous tissue disorders: Sweating, papular rash.
Musculoskeletal and connective tissue disorders: Muscle twitching, joint swelling, muscle cramp, myalgia, arthralgia, back pain, pain in limb, muscle stiffness.
Renal and urinary disorders: Dysuria, urinary incontinence.
Reproductive system and breast disorders: Ejaculation delayed, sexual dysfunction.
General disorders and administration site conditions: Chest tightness, fall, generalized oedema, pain, chills, asthenia, thirst.
Investigations: Alanine aminotransferase increased, blood creatine phosphokinase increased, aspartate aminotransferase increased, platelet count decreased.
Rare (<1:1,000): Blood and lymphatic system disorders: Neutropenia.
Metabolism and nutrition disorders: Hypoglycaemia.
Psychiatric disorders: Disinhibition, elevated mood.
Nervous system disorders: Hypokinesia, parosmia, dysgraphia.
Eye disorders: Photopsia, eye irritation, mydriasis, oscillopsia, altered visual depth perception, peripheral vision loss, strabismus, visual brightness.
Cardiac disorders: Sinus tachycardia, sinus arrhythmia, sinus bradycardia.
Respiratory, thoracic and mediastinal disorders: Nasal congestion, epistaxis, rhinitis, snoring, throat tightness.
Gastrointestinal disorders: Ascites, dysphagia, pancreatitis.
Skin and subcutaneous tissue disorders: Cold sweat, urticaria.
Musculoskeletal and connective tissue disorders: Cervical spasm, rhabdomyolysis, neck pain.
Renal and urinary disorders: Oliguria, renal failure.
Reproductive system and breast disorders: Amenorrhoea, breast discharge, breast pain, dysmenorrhoea, breast enlargement.
General disorders and administration site conditions: Pyrexia.
Investigations: Blood glucose increased, blood creatinine increased, blood potassium decreased, weight decreased, white blood cell count decreased.
Unknown frequency: Immune system disorders: Angioedema, allergic reaction, hypersensitivity.
Nervous system disorders: Headache, loss of consciousness, mental impairment.
Eye disorders: Keratitis.
Cardiac disorders: Congestive heart failure.
Respiratory, thoracic and mediastinal disorders: Pulmonary oedema.
Gastrointestinal disorders: Swollen tongue, diarrhea, nausea.
Skin and subcutaneous tissue disorders: Face swelling, pruritus.
Renal and urinary disorders: Urinary retention.
Reproductive system and breast disorders: Gynaecomastia.
General disorders and administration site conditions: Malaise.