Toprelin

Toprelin Dosage/Direction for Use

pregabalin

Manufacturer:

T. O. Chemicals

Distributor:

T. O. Chemicals
Full Prescribing Info
Dosage/Direction for Use
The dose range of pregabalin is 150 to 600 mg daily administered in 2 or 3 divided doses.
Adult dosage: Neuropathic Pain: Pregabalin treatment can be started at a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after an interval of 3 to 7 days, and if needed, to a maximum dose of 600 mg per day after an additional 7-day interval.
Epilepsy: Pregabalin treatment can be started with a dose of 150 mg per day. Based on individual patient response and tolerability, the dosage may be increased to 300 mg per day after 1 week. The maximum dosage of 600 mg per day may be achieved after an additional week.
Generalized Anxiety Disorder: The recommended dose range is 150-600 mg daily administered 2 or 3 divided doses. The need for treatment should be reassessed regularly.
Dosing should begin at 150 mg daily and may be increased to 300 mg daily within 1 week based on efficacy and tolerability. Patients who do not experience sufficient benefit with 300 mg daily may be further increase to 450 mg daily after 1 week. If needed, in some patients, based on individual response and tolerability, the dose may be increased to maximum dosage of 600 mg daily after an additional week.
Fibromyalgia: The recommendation dosage of pregabalin is 300-450 mg daily. Pregabalin therapy generally is initiated at a dosage of 150 mg daily (75 mg twice daily); dosage may be increased to 300 mg daily (150 mg twice daily) within 1 week based on efficacy and tolerability. Patients who do not experience adequate benefit with pregabalin 300 mg daily may have dosage further increased to the maximum recommended dosage of 450 mg daily (225 mg twice daily). The maximum dosage of 600 mg per day may be achieved after an additional week.
Discontinuous of pregabalin: It is recommended that this should be tapered gradually over a minimum of 1 week.
Use in special populations: Patients with renal impairment: Dosage reduction in patients with compromised renal function must be individualized according to creatinine clearance (CLcr), (see Pharmacology: Pharmacokinetics: Special populations under Actions), as indicated in the Table determined using the following formula: See Equation.

Click on icon to see table/diagram/image

For patients receiving hemodialysis, the pregabalin daily dose should be adjusted based on renal function. In addition to the daily dose, a supplementary dose should be given immediately following every 4-hour hemodialysis treatment (see Table).

Click on icon to see table/diagram/image

Elderly: Dosage reduction required in elderly patients with renal impairment. (See Pharmacology: Pharmacokinetics: Special populations under Actions).
Mode of Administration: The total daily dose is 150 to 600 mg administered orally in either two or three divided dose. The capsule should be taken with or without food.
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