Toprelin Drug Interactions



T. O. Chemicals


T. O. Chemicals
Full Prescribing Info
Drug Interactions
Based on results of in vitro studies, pregabalin does not appear to inhibit cytochrome P450 (CYP) isoenzymes 1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4 or induce CYP1A2 or CYP3A4. According to the original manufacturer, an increase in metabolism of concomitantly administered CYP1A2 substrates (e.g., caffeine, theophylline) or CYP3A4 substrates (e.g., midazolam, testosterone) is not anticipated.
Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans and does not bind to plasma proteins, its pharmacokinetics are unlikely to be affected by other agents through metabolic interactions or protein binding displacement.
ACE-inhibitors: Coadministration of these agents may increase the risk of swelling and hives.
Antiepileptic drugs (carbamazepine, valproic acid, lamotrigine, phenytoin, phenobarbital, topiramate, gabapentin and tiagabine): Pharmacokinetic interactions are unlikely to occur.
Ethanol, lorazepam, oxycodone: Although no pharmacokinetic interactions were seen, additive effects on cognitive and gross motor functioning occurred. No clinically important effects on respiration were seen. Instruct patients to avoid alcohol.
Oral contraceptives (norethindrone and/or ethinyl estradiol): Pharmacokinetic interactions are unlikely to occur.
Oral antidiabetics (glyburide and metformin), diuretic (furosemide) and insulin: These drugs do not appear to affect the pharmacokinetics of pregabalin.
Thiazolidinedione antidiabetic agents (e.g., pioglitazone, rosiglitazone): Co-administration of pregabalin and a thiazolidinedione may lead to additive effect on edema and weight gain, possibly exacerbating or leading to heart failure. If an interaction is suspected, it may need to adjust the dose of one or both agents.
Drug/Food Interactions: The rate of pregabalin absorption is decreased when given with food, resulting in a decrease in Cmax of approximately 25-30% and an increase in Tmax to approximately 3 hours. However, administration of pregabalin with food has no clinically relevant effect on the total absorption of pregabalin. Therefore, pregabalin can be taken with or without food.
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